a) Background Omega Fund Management, LLC (“Omega US” or the “Adviser”) is an investment adviser offering investment advisory services with respect to securities of companies active in the life sciences field. Omega US is part of the Omega Group (“Omega”), which includes Clessidra, LLC (“Clessidra”) and NeoMed Sàrl (“NeoMed”). Clessidra is a US limited liability company and NeoMed is a 100% owned subsidiary that is based in Switzerland. Omega was originally founded in November 2004, with its U.S. operations (Omega US) established in February 2006. The members/owners of Omega US are Francesco Draetta, Claudio Nessi and Clessidra, with Otello Stampacchia being the sole member of Clessidra. For purposes of this brochure, “Omega US” or the “Adviser” shall include (where the context permits) the affiliated general partners of the Fund (as defined below). Such general partners are under common control with Omega Fund Management, LLC. b) Advisory Services Omega US offers investment advice to private investment funds (the “Funds”) that are exempt from registration under the Investment Company Act of 1940, as amended (the “Investment Company Act”), and whose securities are not registered under the Securities Act of 1933, as amended (the Securities Act”), and certain other investment advisors. The principal activity of the Funds is to acquire, hold and dispose of investments in equity securities of companies active in the life sciences field. Omega US advises the Funds on a discretionary basis. Omega US provides advice with respect to companies and portfolios of companies and the general partner of each of the Funds, each an Omega affiliate, makes investment decisions for such Fund. The Limited Partners of, or other investors in, the Funds have no opportunity to select or evaluate any Fund investments or strategies. Omega selects all investments and strategies. Omega US’s advisory services consist of investigating, identifying and evaluating investment opportunities, structuring, negotiating and making investments on behalf of the Funds, managing and monitoring the performance of such investments and disposing of such investments. Omega US provides investment supervisory services to each Fund in accordance with the limited partnership agreement (or analogous organizational document) of such Fund or separate investment and advisory, investment management or portfolio management

agreements. c) Tailored Advice and Client-Imposed Restrictions Each Omega advisory relationship and each Fund has its own investment objectives, strategies and restrictions. Certain relationships and Funds focus on a narrow investment strategy, while others may pursue a broader investment strategy. Omega’s agreement with an advisory client can set forth objectives, strategies, restrictions and limitations governing such advisory relationship. Omega prepares offering materials with respect to each Fund, which contain more detailed information, including a description of the investment objective and strategy or strategies employed and related restrictions and limitations. While Omega’s advisory agreement with respect to an advisory relationship is reasonably tailored based on the individual needs of an advisory client, none of the Funds is tailored to meet the individualized investment needs of any particular investor (“Investor”). An investment in a Fund does not create a client-adviser relationship between Omega and an Investor. Further discussion of the strategies, investments and risks associated with a Fund are included in the offering memorandum and agreements governing such Fund. Investment advice is provided directly to the Funds, subject to the discretion and control of the applicable general partner, and not individually to the Investors. Services are provided to the Funds in accordance with the advisory agreements with the Funds and/or organizational documents of the applicable Fund. Clients and Investors must consider whether a particular advisory relationship or Fund, respectively, is appropriate to their own circumstances based on all relevant factors including, but not limited to, the Client’s or Investor’s own investment objectives, liquidity requirements, tax situation and risk tolerance, among other considerations. Prospective Clients and Investors are strongly encouraged to undertake appropriate due diligence, including but not limited to a review of relevant advisory agreements or offering materials for the Funds, as applicable, and the additional details about Omega’s investment strategies, methods of analysis and related risks in Item 8 of this Brochure, before making an investment decision. d) Wrap Fee Disclosure Not applicable. e) Assets under Management As of December 31, 2023, Omega had $1,592,308,964 of regulatory assets under management, all managed on a discretionary basis.