RA Capital provides discretionary investment advisory services to RA Capital Healthcare Fund, L.P. (the “Healthcare Fund,” or, as the context requires, the “Healthcare Master Fund”), RA Capital Healthcare International Fund, Ltd. (the “Healthcare Offshore Fund”), RA Capital Nexus Fund, L.P. (“Nexus Fund” or, as the context requires, the “Nexus Master Fund”), RA Capital Nexus International Fund, L.P. (“Nexus Offshore Fund”), RA Capital Nexus Fund II, L.P. (“Nexus II” or, as the context requires, the “Nexus II Master Fund”), RA Capital Nexus International Fund II, L.P. (“Nexus II Offshore Fund”), RA Capital Nexus Fund III, L.P. (“Nexus III” or, as the context requires, the “Nexus III Master Fund”), RA Capital Nexus International Fund III, L.P. (“Nexus III Offshore Fund”), and a separately managed account (the “Account”). RA Capital was organized under the laws of the Commonwealth of Massachusetts in 2004 and converted into a Delaware limited partnership in November 2019. These terms have the following meanings, as used in this Brochure: The “Healthcare Funds” means Healthcare Fund and Healthcare Offshore Fund. The “Nexus Funds” means Nexus Fund, Nexus II, Nexus III, Nexus Offshore Fund, Nexus II Offshore Fund, and Nexus III Offshore Fund. The “Master Funds” means Healthcare Fund, Nexus Fund, Nexus II and Nexus III. The “Offshore Funds” means Healthcare Offshore Fund, Nexus Offshore Fund, Nexus II Offshore Fund, and Nexus III Offshore Fund. The “Funds” means both the Healthcare Funds and the Nexus Funds. The “Advisory Clients” means the Funds and the Account. The Funds are open only to certain financially sophisticated and high net-worth individuals and entities, as more fully discussed in Item 7, and are organized in a master-feeder structure, with each of Healthcare Offshore Fund, Nexus Offshore Fund, Nexus II Offshore Fund, and Nexus III Offshore Fund investing substantially all of their capital in Healthcare Master Fund, Nexus Master Fund, Nexus II Master Fund, and Nexus III Master Fund, respectively. RA Capital is principally owned by Peter Kolchinsky, Ph.D., and Rajeev Shah (the “Portfolio Managers”). RA Capital focuses its investment advisory services on securities relating to the healthcare and life sciences industries. The terms and investment objectives and strategies applicable to the Funds are set forth in their respective confidential private placement memoranda, or similar documents, provided to investors prior to the time of their investment. RA Capital has broad and flexible investment authority with respect to the Funds. The Healthcare Funds are hedge funds making long, short, and private investments in the securities of companies primarily in the healthcare and life sciences industries and the Nexus Funds are venture funds making primarily private investments in healthcare and life sciences companies. RA Capital provides discretionary investment advisory services to the Account, which is

not making any new investments but which does still hold legacy investments. RA Capital tailors its advice to the objectives of its Advisory Clients. RA Capital does not tailor its advice to the objectives of underlying investors in the Funds (“Fund Investors”). The Healthcare Fund Investors are required to participate in private, side-pocket investments in the Healthcare Funds and must select a percentage (not to be less than 20% and not to exceed 80%) of their investment that is eligible for participation in such private, side-pocket investments. RA Capital owners and certain other personnel, as individual Fund Investors, or through RA Capital, also participate in such private, side-pocketed investments. RA Capital has established, and may in the future establish, separately managed accounts for particular Investors. These accounts are subject to investment objectives, guidelines, restrictions, fee arrangements, and other terms that are individually negotiated, and generally involve significant minimum initial investments. RA Capital and its personnel are permitted to engage in business activities in addition to the investment advisory activities described in this Item 4. The principals of RA Capital are not required to devote a particular amount of time to RA Capital’s advisory activities. RA Capital’s affiliate, RA Capital Nexus Fund III GP, LLC, serves as general partner of Nexus III and the Nexus III Offshore Fund. RA Capital’s affiliate, RA Capital Nexus Fund II GP, LLC, serves as general partner of Nexus II and the Nexus II Offshore Fund. RA Capital’s affiliate, RA Capital Nexus Fund GP, LLC, serves as general partner of the Nexus Fund and the Nexus Offshore Fund. RA Capital's affiliate, RA Capital Healthcare Fund GP, LLC, serves as general partner of the Healthcare Master Fund. RA Capital currently serves as investment adviser of the Healthcare Funds, the Nexus Funds, and the Account. The general partners are owned and controlled by Messrs. Kolchinsky and Shah. Mr. Richard H. Aldrich is a passive minority owner of RA Capital and is not involved in the day-to-day management of the Adviser or any Advisory Client account. As of December 31, 2021, RA Capital has approximately $10,147,001,376.00 of Regulatory Assets Under Management (calculated under the guidance in Form ADV instructions), all managed on a discretionary basis. Information about the Funds presented in this Brochure is indicative of Fund terms and practices. Fund interests are offered to eligible investors only through their respective private placement memoranda and other offering and governing documents, which should be read in their entirety prior to investment. This Brochure is not an offer of interests in any Fund. Unless otherwise specified, throughout this document the term “Chief Compliance Officer” or “CCO” refers to RA Capital’s Chief Compliance Officer and/or other members of RA Capital’s compliance team.